Prolonged Ketamine Infusion Induces Sustained Remission of Treatment-Resistant Depression (1 CE)
This course is for: Clinical Psychologists, Counselors and Nurses
Course By: Tamara Avery, PsyD
Content By: Siegel, J. S., Palanca, B. J. A., Ances, B. M., Kharasch, E. D., Schweiger, J. A., Yingling, M. D., Snyder, A. Z., Nicol, G. E., Lenze, E. J. & Farber, N. B. (2021). Prolonged ketamine infusion modulates limbic connectivity and induces sustained remission of treatment-resistant depression. Psychopharmacology, 238, 1157-1169. https://doi.org/10.1007/s00213-021-05762-6
Course Description: Monoaminergic antidepressant medications work slowly and require compliance, and, in many cases, are either not tolerated or not sufficient to produce remission of symptoms. The limited targeting and slow rate of response of conventional antidepressants have motivated alternative pharmacologic approaches. Ketamine is an alternative treatment approach that produces a rapid antidepressant response in over 50% of adults with treatment-resistant depression. The study aimed to replicate and expand the previous 96-h ketamine infusions and to use resting-state functional MRI (rsfMRI) to assess potential neurobiological correlates of ketamine’s antidepressant effects. Researchers found that a single prolonged infusion of ketamine provides a tolerated, rapid, and sustained response in treatment-resistant depression and normalizes depression-related hyperconnectivity in the limbic system and frontal lobe.
- Identify the purposes of the study and the methods related to prolonged ketamine infusion as examined in the article
- Analyze the data by exploring the statistical tests used in conjunction with the discussed findings
- Integrate the study limitations with the identified areas of future research
- Read and understand Prolonged ketamine infusion modulates limbic connectivity and induces sustained remission of treatment-resistant depression
- Review the Course Description and Learning Objectives
- Consider the factors related to functional connectivity in pre- and post-infusion coupled with the statistical findings from the accompanying article
- Work through the post-test questions; keep in mind that answer selections should be derived from the respective article
- Return to the article for clarification regarding treatment-dependent connectivity changes, or for any missed questions
Implicit biases incorporate an association that occurs outside of conscious awareness that may resultantly lead to a negative patient evaluation derived from irrelevant characteristics, i.e., gender and/or race. A systematic review of the literature was conducted. Thirty-five studies identified the existence of implicit bias in healthcare professionals; all correlational studies evidenced a significant positive relationship between implicit bias levels and lower quality of care (FitzGerald & Hurst, 2017). Continued research in health care settings, combined with greater method homogeneity, should be employed to examine the occurrence and prevalence of implicit biases in healthcare settings as a strategic approach for mitigating related disparities (FitzGerald & Hurst, 2017).
FitzGerald, C., Hurst, S. (2017). Implicit bias in healthcare professionals: a systematic review. BMC Med Ethics 18, 19. https://doi.org/10.1186/s12910-017-0179-8
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